Fig. 4
From: Targeting MCL-1 in cancer: current status and perspectives
Co-crystal structures of MCL-1 in complex with its inhibitor. a MCL-1/S63845 complex (PDB: 5LOF), b MCL-1/S64315 complex (PDB: 6YBL), c MCL-1/AZD5991 complex (PDB: 6FS0), D. MCL-1/AM-8621 complex (PDB: 6OQB), e MCL-1/VU661013 complex (PDB: 6NE5), f MCL-1/A-1210477 lead compound complex (PDB: 5VKC). The four hydrophobic pockets (P1-4) and Arg263 are highlighted and labelled. g MCL-1 hot-spots residues for P1-P4 pockets and the four hydrophobic residues of BIM (h1, h2, h3, h4) based on the MCL-1/BIM structure (PDB: 2NL9)