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Table 4 The PK profiles of PF-06840003

From: Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Species CL (mL/min/kg) Vss (L/kg) t1/2 (h) F (%) AUC (ng h/mL)
Rat 3.7 0.639 2.42 94.0 6940
Dog 24.3 0.957 0.840 18.6 237
Human 0.64 1.1 19 64 ND
  1. CL, plasma clearance; Vss, volume distribution stead state; t1/2, half-life; F, Oral bioavailability; AUC, area under the concentration-time curve