Table 4 The PK profiles of PF-06840003
From: Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
Species | CL (mL/min/kg) | Vss (L/kg) | t1/2 (h) | F (%) | AUC (ng h/mL) |
|---|---|---|---|---|---|
Rat | 3.7 | 0.639 | 2.42 | 94.0 | 6940 |
Dog | 24.3 | 0.957 | 0.840 | 18.6 | 237 |
Human | 0.64 | 1.1 | 19 | 64 | ND |