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Table 6 Comparison of pharmacokinetics after a single dose of 5 or 6 in mice

From: Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Compound Dose (μM/kg) Cmax (μM) AUC0–24 (μM h) t1/2 (h)
Indoximod (5) 143 9.3 ± 2.2 36.4 ± 9 3
  287 17.2 ± 3.7 77.7 ± 21.6 2.8
  573 26 ± 11.1 153.6 ± 79.2 3.1
  1147 51.7 ± 25.4 348.2 ± 115.2 3.4
NLG802 (6) 143 35 ± 25.3 105.4 ± 68.5 2.9
  287 68.9 ± 3.9 142.3 ± 64.6 2.2
  573 65.7 ± 34.1 150.8 ± 76.1 3.1
  1147 101.4 ± 38.9 374.3 ± 180.7 3.2
  1. Cmax, maximum concentration observed in plasma; AUC0–24, area under the plasma concentration-time curve from 0 to 24 h of quantifiable concentration; t1/2, half-life