Skip to main content

Table 1 Bispecific T cell-recruiting antibodies for the treatment of hematologic malignancies

From: Bispecific T cell engagers: an emerging therapy for management of hematologic malignancies

Disease

Target

Name

Antibody format

AML

CD123-CD3

MGD006

DART

  

XmAb14045

XmAb

 

CD33-CD3

AMG 330

BiTE

  

AMV 564

TandAb

 

FLT3-CD3

7370

BiTE

 

CLEC12A-CD3

MCLA-117

Biclonics

 

WT1-CD3

ESK1-BiTE

BiTE

ALL

CD19-CD3

Blinatumomab

BiTE

  

AFM11

TandAb

MM

BCMA-CD3

AMG420

BiTE

  

AMG701

BiTE-Fc

 

GPRC5D-CD3

Talquetamab

DuoBody

 

CD38-CD3

AMG424

XmAb

  

Bi38-3

BiTE

 

FCRL5-CD3

anti-FcRH5/CD3 TDB

Knobs-into-holes

NHL

CD19-CD3

Blinatumomab

BiTE

 

CD20-CD3

REGN1979

Veloci-Bi platform

  

Mosunetuzumab

Knobs-into-holes

  

RG6026

2:1 CrossMab

MDS

CD33-CD3

AMV564

TandAb

 

CD123-CD3

MGD006

DART