Fig. 3

Association of ctDNA analyses with early detection of recurrence. a Kaplan–Meier curves of recurrence-free survival of the 125 patients who were included in the serial post-definitive treatment analysis, stratified by serial ctDNA status. b ctDNA profiling results and the corresponding clinical courses of the 23 relapsed patients included in the serial post-definitive treatment analysis. c Comparison of time from surgery to disease recurrence by ctDNA and computed tomography (CT) scanning, dashed lines indicate mean time of recurrence based on CT (13.70 months) and ctDNA (8.69 months). (N = 19, Student’s t test)