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Table 1 Univariate and multivariate Cox analysis of recurrence-free survival by clinicopathological variables and ctDNA status at 3–7 days postoperation

From: Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer

Variable Univariate analysis Multivariate analysis
HR (95% CI) P* HR (95% CI) P*
Age, years     
≤ 60 versus > 60 1.44 (0.71–2.91) 0.313   
Sex     
Male versus female 0.74 (0.37–1.47) 0.387   
Primary tumor location     
Right-sided versus left-sided 1.87 (0.93–3.74) 0.077   
Pathological stage     
III versus II 2.26 (1.07–4.79) 0.032 1.18 (0.50–2.77) 0.706
Lymphovascular invasion     
Yes versus no 2.60 (1.30–5.22) 0.007 1.53 (0.67–3.48) 0.316
Nerve invasion     
Yes versus no 2.04 (1.02–4.08) 0.045 1.99 (0.90–4.39) 0.091
Histological type     
Mucinous versus adenocarcinoma 0.90 (0.27–2.94) 0.856   
Histological grade     
Poor versus medium/well 0.88 (0.38–2.03) 0.757   
MSI status     
MSI-L/MSS versus MSI-H 0.99 (0.30–3.24) 0.984   
Preoperative ctDNA status     
Positive versus negative 5.66 (1.72–18.57) 0.004 3.79 (1.12–12.86) 0.032
ctDNA status at day 3–7 postoperation     
Positive versus negative 10.98 (5.31–22.72) < 0.001 8.02 (3.59–17.92) < 0.001
  1. *P value in bold denotes statistically significant