|
Variable
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
HR (95% CI)
|
P*
|
HR (95% CI)
|
P*
|
|---|
|
Age, years
| | | | |
|
≤ 60 versus > 60
|
1.44 (0.71–2.91)
|
0.313
| | |
|
Sex
| | | | |
|
Male versus female
|
0.74 (0.37–1.47)
|
0.387
| | |
|
Primary tumor location
| | | | |
|
Right-sided versus left-sided
|
1.87 (0.93–3.74)
|
0.077
| | |
|
Pathological stage
| | | | |
|
III versus II
|
2.26 (1.07–4.79)
|
0.032
|
1.18 (0.50–2.77)
|
0.706
|
|
Lymphovascular invasion
| | | | |
|
Yes versus no
|
2.60 (1.30–5.22)
|
0.007
|
1.53 (0.67–3.48)
|
0.316
|
|
Nerve invasion
| | | | |
|
Yes versus no
|
2.04 (1.02–4.08)
|
0.045
|
1.99 (0.90–4.39)
|
0.091
|
|
Histological type
| | | | |
|
Mucinous versus adenocarcinoma
|
0.90 (0.27–2.94)
|
0.856
| | |
|
Histological grade
| | | | |
|
Poor versus medium/well
|
0.88 (0.38–2.03)
|
0.757
| | |
|
MSI status
| | | | |
|
MSI-L/MSS versus MSI-H
|
0.99 (0.30–3.24)
|
0.984
| | |
|
Preoperative ctDNA status
| | | | |
|
Positive versus negative
|
5.66 (1.72–18.57)
|
0.004
|
3.79 (1.12–12.86)
|
0.032
|
|
ctDNA status at day 3–7 postoperation
| | | | |
|
Positive versus negative
|
10.98 (5.31–22.72)
|
< 0.001
|
8.02 (3.59–17.92)
|
< 0.001
|
- *P value in bold denotes statistically significant
