Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer

Table 1 Univariate and multivariate Cox analysis of recurrence-free survival by clinicopathological variables and ctDNA status at 3–7 days postoperation

Variable	Univariate analysis		Multivariate analysis
Variable	HR (95% CI)	P*	HR (95% CI)	P*
Age, years
≤ 60 versus > 60	1.44 (0.71–2.91)	0.313
Sex
Male versus female	0.74 (0.37–1.47)	0.387
Primary tumor location
Right-sided versus left-sided	1.87 (0.93–3.74)	0.077
Pathological stage
III versus II	2.26 (1.07–4.79)	0.032	1.18 (0.50–2.77)	0.706
Lymphovascular invasion
Yes versus no	2.60 (1.30–5.22)	0.007	1.53 (0.67–3.48)	0.316
Nerve invasion
Yes versus no	2.04 (1.02–4.08)	0.045	1.99 (0.90–4.39)	0.091
Histological type
Mucinous versus adenocarcinoma	0.90 (0.27–2.94)	0.856
Histological grade
Poor versus medium/well	0.88 (0.38–2.03)	0.757
MSI status
MSI-L/MSS versus MSI-H	0.99 (0.30–3.24)	0.984
Preoperative ctDNA status
Positive versus negative	5.66 (1.72–18.57)	0.004	3.79 (1.12–12.86)	0.032
ctDNA status at day 3–7 postoperation
Positive versus negative	10.98 (5.31–22.72)	< 0.001	8.02 (3.59–17.92)	< 0.001

ISSN: 1756-8722