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Table 1 TET2 and DNMT3A mutation status in cancer cell lines

From: TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

Cell line

DNMT3A

TET2

Mutation status; typea

Nucleotide; protein

Mutation status; type

Nucleotide; protein

ACHN

Missense; deleterious

c.2069T > C; p.V690A

Missense; deleterious

c.1088C > T; p.P363L

   

Missense; deleterious

c.5162T > G; p.L1721W

BT549

Missense; deleterious

c.2587G > A; p.E863K

Missense; deleterious

c.1064G > A; p.G355D

   

Missense; deleterious

c.4117G > A; p.A1373T

SKMEL5

Missense

c.736G > T; p.A246S

Missense; deleterious

c.1430C > T; p.S477F

NCI-H23

Nonsense

c.667G > T; p.G223X

Missense; deleterious

c.5162T > G; p.L1721W

SKMEL2

Wildtypeb

Missense; deleterious

c.5162T > G; p.L1721W

DU145

Wildtype

Missense; deleterious

c.5162T > G; p.L1721W

KM12

Missense; deleterious

c.2283G > A; p.M761I

Missense

c.5284A > G; p.I1762V

OVCAR3

Wildtype

Wildtype

COLO205

Wildtype

Wildtype

MDA231

Wildtype

Missense; deleterious

c.5162T > G; p.L1721W

MCF7

Wildtype

Missense; deleterious

c.86C > G; p. P29R

M14

Wildtype

Wildtype

EKVX

Missense; deleterious

c.2375G > A; p.R792H

Missense

c.5284A > G; p.I1762V

T47D

Wildtype

Missense; deleterious

c.5162T > G; p.L1721W

SKOV3

Wildtype

Wildtype

HCT116

Wildtype

Missense

c.5284A > G; p.I1762V

HCT15

Missense; deleterious

c.2283G > A; p.M761I

Missense

c.5284A > G; p.I1762V

  1. aPredicted by SIFT (sorting intolerant from tolerant) and/or PolyPhen (polymorphism phenotyping)
  2. bWildtype also refers to the synonymous variants