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Table 2 Clinical applications of piRNAs in cancer

From: The biogenesis and biological function of PIWI-interacting RNA in cancer

piRNA

Cancer

Sample type

Expression in tumors

Diagnosis biomarker

Prognostic biomarkers

Chemoresistance

Therapeutic targets

Clinical relevance

References

piR-36712

Breast cancer

Tissues

↓

√

√

√

√

Metastatic

[22]

piR-932

Cell lines

↑

    

–

[108]

piR-4987

Tissues

↑

√

   

Metastatic

[113]

piR-20365

Tissues

↑

√

   

–

[113]

piR-20485

Tissues

↑

√

   

–

[113]

piR-20582

Tissues

↑

√

   

–

[113]

piR-sno75

Cell lines/tissues

↓

  

√

√

–

[34]

piR-10506469

CHOL

Plasma exosomes

↑

√

   

–

[105]

piR-24000

Colorectal Cancer

Tissues

↑

√

   

Metastatic, differentiation, tumor stage

[13]

piR-020619

Serum

↑

√

   

–

[107]

piR-020450

Serum

↑

√

   

–

[107]

piR-54265

Serum

↑

√

  

√

Tumor stage, relapse

[104]

piR-823

Tissues

↑

 

√

 

√

Metastatic, tumor stage, Adjuvant chemotherapy

[14, 68]

piR-017724

Serum

↓

   

√

–

[109]

piR-18849

Tissues

↑

 

√

  

Metastatic, differentiation

[17]

piR-19521

Tissues

↑

 

√

  

Metastatic, differentiation

[17]

piR-1245

Tissues

↑

 

√

  

Metastatic

[18]

piR-54265

Tissues

↑

 

√

√

√

–

[19]

piR-5937

Serum

↓

√

   

–

[114]

piR-28876

Serum

↓

√

   

–

[114]

piR-30473

DLBCL

Tissues

↑

 

√

  

–

[10]

piR-823

ESCC

Tissues

↑

√

√

  

Metastatic

[63]

piR-10506469

Gallbladder carcinoma

Plasma exosomes

↑

√

   

Tumor stage

[105]

piR-1245

Gastric cancer

Gastric juice

↑

√

   

Tumor stage, tumor size

[15]

piR-823

Tissues

↓

   

√

–

[71]

piR-651

Tissues

↑

√

  

√

–

[16]

piR-8041

Glioblastoma

Tissues

↓

√

  

√

–

[112]

piR-30188

Tissues

↓

√

   

–

[67]

piR-DQ593109

Glioma

Cell lines

↑

   

√

–

[118]

piR-651

Hematological malignancy

Serum

↑

  

√

 

–

[21]

piR-823

Cell lines

↑

    

Tumor stage

[61]

piR-823

Cell lines

↑

   

√

Tumor stage

[72]

piR-004800

Cell lines/exosomes

↑

   

√

–

[79]

piR-34736

HNSCC

Tissues

↑

√

   

–

[116]

piR-34536

Kidney cancer

Tissues/serum

↓

 

√

  

–

[110]

piR-51810

Tissues/serum

↓

 

√

  

Metastatic

[110]

piR-32051

Tissues

↑

√

   

–

[7]

piR-43607

Tissues

↑

 

√

  

–

[7]

piR-39894

Tissues

↑

√

   

Metastatic

[7]

piR-57125

Tissues

↓

 

√

  

Relapse

[89]

piR-30924

Tissues

↑

 

√

  

Relapse

[89]

piR-38756

Tissues

↑

 

√

  

–

[89]

piR-823

Tissues

↓

 

√

  

–

[115]

piR-651

Lung cancer

Tissues

↑

√

  

√

Tumor stage, relapse

[11, 12]

piR-55490

Tissues

↓

 

√

  

–

[66]

piR-L-138

Cell lines

↑

  

√

  

[111]

piR-39980

Neuroblastoma

Cell lines

↑

  

√

 

–

[20]

piR-017061

pancreatic cancer

Tissues

↓

√

   

–

[117]

piR-21238

PTC

Tissues

↑

√

   

Tumor stage

[106]

piR-13643

Tissues

↑

√

   

Tumor stage

[106]

  1. CHOL cholangiocarcinoma, DLBCL diffuse large B-cell lymphoma, ESCC esophageal squamous cell carcinoma, HNSCC head and neck squamous cell carcinoma, PTC papillary thyroid carcinoma