Skip to main content
Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia

Fig. 7

Combined inhibition of NOTCH1 and nuclear export prolongs survival in T-ALL. a Schematic representation of the experiment. b Evolution of bioluminescence signal (left) and percentage of hCD45+ cells in peripheral blood (right) over time, every dot represents an animal. Grey area represents the treatment period. c Bioluminescence analysis measured by maximum total flux (p/s) at day 14 and day 29 for each mouse; mean and standard deviation are noted. Bioluminescence imaging overlays are (right panel) shown for reference. Data were analyzed by one-way ANOVA with Bonferroni correction for multiple comparisons. d Kaplan–Meier survival plots for X10-luc mice. Data were analyzed using the log-rank Mantel–Cox test. e Scatter dot plot of survival in days from start of treatment for each mouse. Line represents median for each treatment group. Data were analyzed using one-way ANOVA for matched data with Bonferroni multiple comparisons correction. f Kaplan–Meier plot for survival, starting from death of vehicle. Data were analyzed using the log-rank Mantel–Cox test. ns = not significant (p > 0.05), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

Back to article page