Fig. 3
From: Molecular pathogenesis of the myeloproliferative neoplasms
Mutational significance in MPN for overall survival. A summary of determined mutational significance in MPN. The central figure shows genetic contributors to fibrotic (inner yellow ring) and leukaemic (outer red ring) transformation in MPN determined by a predictive modelling approach in 1599 chronic phase and 276 myelofibrosis patients [15]. Underlined genes were contributors to death in myelofibrosis patients in this modelling. Overlaid are a purple ring (A) showing independent risk factors for survival identified in 641 myelofibrosis patients [101], a green ring (B) showing independent risk factors for survival identified in 483 myelofibrosis patients and validated in a further 396 patients [98], and finally a grey ring (C) showing prognostically detrimental genes in 537 myelofibrosis patients and validated in a further 260 patients [102]