Precision oncology in AML: validation of the prognostic value of the knowledge bank approach and suggestions for improvement

Table 1 Predicted and observed frequencies of additional genetic markers in AML patients alive and those who were dead 3 years after diagnosis

Characteristic	Patients alive			Patients dead
Characteristic	Correctly predicted alive (%) n = 300	Falsely predicted dead (%) n = 222	p*	Falsely predicted alive (%) n = 368	Correctly predicted dead (%) n = 722	p*
AXL, mutated	1	2	< 0.001	3	0	0.09
NOTCH1, mutated	3	1	< 0.001	1	3	0.18
SAMHD1, mutated	1	2	0.04	1	0	0.04
Atypical complex karyotype, present	2	5	0.005	0	3	0.01
Recurrent but infrequent balanced rearrangements, present	1	2	0.04	0	2	0.17

*p-values for categorical variables are from Fisher’s exact test. p-values for continuous variables are from Wilcoxon rank sum test

ISSN: 1756-8722