Fig. 1

Comparison of relative Q-TWiST gains across sensitivity analysis variations. Parameter variations in the Q-TWiST calculation included population (ITT population or safety population), type of toxicity (any grade 3 to 4 AEs or only treatment-related grade 3 to 4 AEs), TOX state health utility weight (0, 0.5, and 1.0), and REL state health utility weight (0, 0.5, and 1.0). For all analyses, TWiST state health utility weight was kept at a constant of 1.0. Across the sensitivity analyses, the relative Q-TWiST gains for CPX-351 versus 7 + 3 were consistently above the clinically important difference of 15% (shown by the yellow line). Q-TWiST, Quality-adjusted Time Without Symptoms of disease or Toxicity; ITT, intent-to-treat; AE, adverse event; TOX, time with any grade 3 or 4 AE or before relapse; REL, time after relapse; TWiST, time in remission and without relapse or grade 3 or 4 AEs