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Table 2 Base case Q-TWiST analysis for patients receiving CPX-351 or 7 + 3

From: Quality-adjusted Time Without Symptoms of disease or Toxicity (Q-TWiST) analysis of CPX-351 versus 7 + 3 in older adults with newly diagnosed high-risk/secondary AML

 

Mean (SD) duration of health state, days

Means difference (95% CI), days

CPX-351 (n = 153)

7 + 3 (n = 156)

Health state

   

 TOX

192 (356)

185 (273)

7 (− 63, 78)

 TWiST

356 (635)

174 (451)

183 (60, 306)

 REL

31 (96)

9 (34.5)

22 (5, 38)

Q-TWiST

468 (623)

271 (449)

197 (76, 319)

Relative Q-TWiST gain

  

53.6%

  1. Q-TWiST, Quality-adjusted Time Without Symptoms of disease or Toxicity; SD, standard deviation; CI, confidence interval; TOX, time with any grade 3 or 4 adverse events or before relapse; TWiST, time in remission without relapse or grade 3 or 4 adverse events; REL, time after relapse