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Table 3 Q-TWiST analysis for patients who achieved CR or CRi with CPX-351 or 7 + 3

From: Quality-adjusted Time Without Symptoms of disease or Toxicity (Q-TWiST) analysis of CPX-351 versus 7 + 3 in older adults with newly diagnosed high-risk/secondary AML

 

Mean (SD) duration of health state, days

Means difference (95% CI), days

CPX-351 (n = 73)

7 + 3 (n = 52)

Health state

   

 TOX

81 (44)

74 (46)

7 (− 9, 23)

 TWiST

747 (744.5)

521 (659)

226 (− 29, 481)

 REL

65 (131.5)

28 (55)

37 (− 2, 75)

Q-TWiST

820 (721)

572 (650)

248 (− 1, 496)

Relative Q-TWiST gain

  

39.8%

  1. Q-TWiST, Quality-adjusted Time Without Symptoms of disease or Toxicity; CR, complete remission; CRi, complete remission with incomplete neutrophil or platelet recovery; SD, standard deviation; CI, confidence interval; TOX, time with any grade 3 or 4 adverse events or before relapse; TWiST, time in remission without relapse or grade 3 or 4 adverse events; REL, time after relapse