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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma

Fig. 2

YTHDF2 could facilitate the malignant phenotype of glioma cells. A YTHDF2 protein expression in glioma cells with or without YTHDF2 siRNA. All of raw images have been shown in Additional file 3. B, C Transwell analysis of cells with or without YTHDF2 siRNA. **P < 0.01 and ***P < 0.001. Bar = 50 μm. D CCK-8 assay (proliferation assay) of cells with or without YTHDF2 siRNA. YTHDF2 siRNA 1 versus scrambled siRNA. **P < 0.01; ***P < 0.001; ****P < 0.0001; YTHDF2 siRNA2 versus scrambled siRNA. #P < 0.05; ####P < 0.0001. E Scratch assay of LN229 cells with or without YTHDF2 siRNA. Bar = 50 μm. F Gap closure rate of cells with or without YTHDF2 siRNA. G YTHDF2 protein expression in glioma cells with or without YTHDF2 overexpression. H, I Transwell analysis of cells with or without YTHDF2 overexpression. ***P < 0.001 and ****P < 0.0001. Bar = 50 μm. J, K CCK-8 assay (proliferation assay) of cells with or without YTHDF2 overexpression. *P < 0.05; **P < 0.01; and ****P < 0.0001. L Scratch assay of LN229 cells with or without YTHDF2 overexpression. Bar = 50 μm. M Gap closure rate of cells with or without YTHDF2 overexpression

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Journal of Hematology & Oncology

ISSN: 1756-8722

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