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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma

Fig. 6

UBXN1 overexpression could attenuate malignant progression and NFKB activation that induced by YTHDF2 overexpression in glioma cells. A CCK-8 assay (proliferation assay) of U87 cells with or without YTHDF2 and UBXN1 OE ****P < 0.0001. B Transwell analysis of U87 cells with or without YTHDF2 and UBXN1 OE. ***P < 0.001. Bar = 50 μm. C YTHDF2, UBXN1, pp65, and p65 protein expression in U87 cells with or without YTHDF2 and UBXN1 OE. D–F Kaplan–Meier curves of gliomas with higher (larger than the median expression levels of respective cohorts) expression YTHDF2 stratified by UBXN1 expression in different datasets

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Journal of Hematology & Oncology

ISSN: 1756-8722

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