Fig. 2

Oncogenic and tumor suppressor pathways altered in STS. (A) This figure highlights mutations that alter regulations of PI3K/AKT/mTOR and MAP kinase pathways in sarcoma. Colored triangles associate sarcoma subtypes (listed on the bottom right corner) with the corresponding genes alterations, either expression or loss, on the scheme. Expression or regulations of tumor suppressor genes is altered (p53, PTEN) concomitantly with increased expression of oncogenes driving malignant transformation (increase Anabolism, Warburg effect). (B) Panel B focuses on cell cycle alterations at the level of the p53 and RB1 tumor suppressor genes notably