Fig. 4
From: N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
Potential approaches for targeting m6A methyltransferases. a Targeting strategy with small-molecule modulators. Schematic domain structure of the METTL3-METTL14 complex with SAM binding (left). STM2457, a catalytic inhibitor of METTL3 that competes with SAM for the SAM-binding pocket, represents the general strategy of m6A methyltransferase modulator development (right). b Targeting strategy related to limit SAM level. Restriction of SAM levels by 3-deazaadenosine (3-DA) reduces m6A levels by blocking SAHH and subsequently elevating SAH levels. Specifically, limiting the level of dietary methionine, which is required for SAM synthesis, can also regulate METTL3 activity. c Targeting strategy for the use of specific miRNAs to inhibit METTL3/METTL14 expression. d Targeting strategy of CRISPR-based site-specific m6A modification