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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: High-resolution Hi-C maps highlight multiscale 3D epigenome reprogramming during pancreatic cancer metastasis

Fig. 2

Contact domain reprogramming during pancreatic cancer metastasis. a Shown is the size of contact domains in 3 cell lines. b Average expression levels of genes (FPKM) located in each histone mark-enriched contact domains and contact domains. c Shown is the size of histone mark-enriched contact domains across 3 cell lines (Wilcoxon rank-sum test in a–c, *p < 0.05, ****p < 0.0001). d An example of contact domain splitting (between the dashed lines) coupled with chromatin state switching (shown by Hi-C maps and histone ChIP-seq tracks) around BCAT1 locus in Capan-1 and PANC-1 cells (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). e BCAT1 expression in normal, primary and metastatic pancreatic cancer cells (****adj. p < 0.0001). f BCAT1 expression in tumor samples with N0 and N1 classification in TCGA PAAD dataset (Student’s t test, **p < 0.01). g Kaplan–Meier survival curves for overall survival for BCAT1 expression in the TCGA PAAD dataset. Whiskers of box plots are from Q1-1.5*IQR to Q3 + 1.5*IQR

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