Fig. 3

Common contact domains with changed chromatin states during pancreatic cancer metastasis. a Pie chart showing that genes located in inactive contact domains of PANC-1 but in active common contact domains of Capan-1 enrich more upregulated genes. b GO enrichment of significantly upregulated genes located in common contact domains that switched from inactive type to active type. c Kaplan–Meier survival analysis of 176 patients with pancreatic cancer from the TCGA PAAD dataset by calculating the gene set enrichment scores (See material and methods) for the significantly upregulated genes in Fig. 4a. d An example of a common contact domain with changed chromatin states (shown by Hi-C maps and histone ChIP-seq tracks) surrounding the TGFA locus (chr2:68,670,001–71,760,001). e TGFA expression in normal, primary and metastatic pancreatic cancer cells. f Kaplan–Meier survival curves for overall survival for TGFA expression in the TCGA PAAD dataset. Whiskers of box plots are from Q1-1.5*IQR to Q3 + 1.5*IQR