Fig. 6

TFs enriched at cell type-specific enhancers that loop to promoters. a The workflow of identification of promoter NDRs and enhancer NDRs by integrating ChIP-seq and ATAC-seq data to find TFs. b Top most frequent TF-binding motifs found in cell type-specific enhancer NDRs that looped to promoters. c Top most frequent TF-binding motifs found in corresponding promoter NDRs. d KLF5 expression in normal, primary, and metastatic pancreatic cancer cells (****adj. p < 0.0001). e KLF5 expression in tumor samples (cancer) and tumor-adjacent normal samples (paracancer) from the TCGA PAAD dataset (Wilcoxon rank-sum test, **p < 0.001). f Kaplan–Meier survival curves for overall survival for KLF5 expression in the TCGA PAAD dataset. g In situ Hi-C maps and histone ChIP-seq tracks surrounding the KLF5 locus in PANC-1 and Capan-1. The enhancer-promoter loops are shown by black arrows. Whiskers of box plots are from Q1-1.5*IQR to Q3 + 1.5*IQR