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Table 1 Markers and functions of cells in TME

From: Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

Cell type Common markers Major role in tumors Effects in B-cell lymphoma References
TAMs M1 CD68+
CD80+
CD86+
Anti-tumorigenic DLBCL: M2 TAMs correlate with poor prognosis
HL: CD68+ TAMs correlate with poor prognosis
FL: High CD68+ TAMs correlate with longer survival rates after R-CHOP
[8,9,10]
M2 CD163+
CD204+
CD206+
Pro-tumorigenic
MDSCs PMN-MDSCs CD11b+
CD14
CD15+
CD66+
Pro-tumorigenic DLBCL: M-MDSCs correlate with poor prognosis
HL: PMN-MDSCs correlate with poor prognosis
FL: Unknown
[11,12,13]
M-MDSCs Lin
CD11b+
CD14+
HLA-DRlow
TANs N1 CD16+
CD66b+
CD170low
Anti-tumorigenic DLBCL: TANs correlate with poor prognosis
HL: High neutrophil‐lymphocyte ratio correlates with poor prognosis in NS-cHL
FL: Unknown
[14,15,16]
N2 CD66b+
CD11b+
CD170high
Pro-tumorigenic
NK cells bone marrow NK cells CD56bright
CD16
Anti-tumorigenic DLBCL: Low NK cells correlate with shorter PFS
HL: Unknown
FL: Low peripheral blood NK cells count correlate with shorter PFS and OS
[17, 18]
mature NK cells CD56dim
CD16+
CAFs α-SMA+
S100A4+
FAP+
CD10+
Pro-tumorigenic DLBCL: CAFs associate with favorable prognosis
HL: CAFs protect Hodgkin and Reed–Sternberg cells from Brentuximab-Vedotin induced injury in NS-cHL
FL: CAFs correlate with poor prognosis
[19,20,21,22]
DCs pDCs CD123+
CD303+
CD304+
Pro-tumorigenic DLBCL: DCs correlate with longer survival
HL: Unknown
FL: Follicular DCs correlate with poor prognosis
[23,24,25]
mDCs CD1c+
CD141+
  1. TME, tumor microenvironment; TAMs, tumor-associated macrophages; MDSCs, myeloid-derived suppressor cells; PMN-MDSCs, polymorphonuclear myeloid-derived suppressor cells; M-MDSCs, monocytic myeloid-derived suppressor cells; TANs, tumor-associated neutrophils; NK cells, natural killer cells; CAFs, cancer-associated fibroblasts; DCs, dendritic cells; pDCs, plasmacytoid dendritic cells; mDCs, myeloid dendritic cells; DLBCL, diffuse large B-cell lymphoma; HL, Hodgkin lymphoma; FL, follicular lymphoma; cHL, classical Hodgkin lymphoma; NS-cHL, nodular sclerosis classical Hodgkin lymphoma