Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

Liu, Yingyue; Zhou, Xiangxiang; Wang, Xin

doi:10.1186/s13045-021-01134-x

Journal of Hematology & Oncology

Table 1 Markers and functions of cells in TME

From: Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

Cell type	Common markers		Major role in tumors	Effects in B-cell lymphoma	References
TAMs	M1	CD68⁺ CD80⁺ CD86⁺	Anti-tumorigenic	DLBCL: M2 TAMs correlate with poor prognosis HL: CD68⁺ TAMs correlate with poor prognosis FL: High CD68⁺ TAMs correlate with longer survival rates after R-CHOP	[8,9,10]
TAMs	M2	CD163⁺ CD204⁺ CD206⁺	Pro-tumorigenic		[8,9,10]
MDSCs	PMN-MDSCs	CD11b⁺ CD14⁻ CD15⁺ CD66⁺	Pro-tumorigenic	DLBCL: M-MDSCs correlate with poor prognosis HL: PMN-MDSCs correlate with poor prognosis FL: Unknown	[11,12,13]
MDSCs	M-MDSCs	Lin⁻ CD11b⁺ CD14⁺ HLA-DR^low	Pro-tumorigenic		[11,12,13]
TANs	N1	CD16⁺ CD66b⁺ CD170^low	Anti-tumorigenic	DLBCL: TANs correlate with poor prognosis HL: High neutrophil‐lymphocyte ratio correlates with poor prognosis in NS-cHL FL: Unknown	[14,15,16]
TANs	N2	CD66b⁺ CD11b⁺ CD170^high	Pro-tumorigenic		[14,15,16]
NK cells	bone marrow NK cells	CD56^bright CD16⁻	Anti-tumorigenic	DLBCL: Low NK cells correlate with shorter PFS HL: Unknown FL: Low peripheral blood NK cells count correlate with shorter PFS and OS	[17, 18]
NK cells	mature NK cells	CD56^dim CD16⁺	Anti-tumorigenic		[17, 18]
CAFs	α-SMA⁺ S100A4⁺ FAP⁺ CD10⁺		Pro-tumorigenic	DLBCL: CAFs associate with favorable prognosis HL: CAFs protect Hodgkin and Reed–Sternberg cells from Brentuximab-Vedotin induced injury in NS-cHL FL: CAFs correlate with poor prognosis	[19,20,21,22]
DCs	pDCs	CD123⁺ CD303⁺ CD304⁺	Pro-tumorigenic	DLBCL: DCs correlate with longer survival HL: Unknown FL: Follicular DCs correlate with poor prognosis	[23,24,25]
DCs	mDCs	CD1c⁺ CD141⁺	Pro-tumorigenic		[23,24,25]

TME, tumor microenvironment; TAMs, tumor-associated macrophages; MDSCs, myeloid-derived suppressor cells; PMN-MDSCs, polymorphonuclear myeloid-derived suppressor cells; M-MDSCs, monocytic myeloid-derived suppressor cells; TANs, tumor-associated neutrophils; NK cells, natural killer cells; CAFs, cancer-associated fibroblasts; DCs, dendritic cells; pDCs, plasmacytoid dendritic cells; mDCs, myeloid dendritic cells; DLBCL, diffuse large B-cell lymphoma; HL, Hodgkin lymphoma; FL, follicular lymphoma; cHL, classical Hodgkin lymphoma; NS-cHL, nodular sclerosis classical Hodgkin lymphoma

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ISSN: 1756-8722

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