|
PTEN mutation or deficiency
|
Prostate cancer, breast cancer, endometrial cancer, glioblastoma, thyroid cancer, etc.
|
[235]
|
|
PIK3CA mutation
|
Breast cancer, ovarian cancer, colorectal cancer, lung cancer, endometrial carcinoma, cervical adenocarcinoma, glioma, head and neck cancer, etc.
|
[234]
|
|
Akt1 E17K
|
Breast cancer, ovarian cancer, endometrial carcinoma, meningioma, etc.
|
[232, 240]
|
|
Activating Akt1/2 indels
|
Breast cancer, prostate cancer, clear cell renal cancer, etc.
|
[239]
|
|
ARID1A/B mutations or deficiency
|
Gastric, ovarian and endometrioid carcinoma, medulloblastoma
|
[245,246,247]
|
|
SF3B1 mutation
|
Myelodysplastic/myeloproliferative neoplasms, melanoma, breast cancer, pancreatic cancer, prostate cancer, AML, etc.
|
[254, 255]
|
|
NPM1 mutation
|
AML
|
[257]
|
|
NM23-H1
|
Breast cancer, melanoma, etc.
|
[248]
|
|
CBL mutation
|
Myeloid neoplasmas
|
[249]
|
|
BTK mutation or deficiency
|
Follicular lymphoma
|
[253]
|
|
GPS2 mutation
|
Breast cancer, medulloblastoma
|
[250,251,252]
|
|
CDH1 mutation or deficiency
|
Gastric cancer, breast cancer, prostate cancer, colorectal cancer, ovarian cancer, etc.
|
[261, 262]
|
|
SMAD4 mutation
|
Colorectal cancer, pancreatic cancer
|
[269, 270]
|
|
GAB2 mutation or amplification
|
Hematological malignancies, ovarian cancer, lung cancer, neuroblastoma, melanoma, breast cancer
|
[264,265,266,267,268]
|
