Skip to main content

Table 2 Effects of native MSC-derived EVs on different types of cancer

From: Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

EV source Cancer Method Key cargo Effect Proposed mechanism Reference
hBMSCs Gastric cancer; colon cancer In vitro and in vivo N/A Angiogenesis↑
Cell proliferation↑
Activation of ERK1/2 and p38 MAPK pathways [37]
hBMSCs Mouse breast cancer In vitro and in vivo miR-16 Angiogenesis↓
Tumor progression↓
VEGF↓ [38]
hBMSCs Breast carcinoma In vitro miR-100 Angiogenesis↓
Endothelial cell proliferation↓
Migration↓
mTOR/HIF-1α/VEGF signaling axis [39]
hMenSCs Prostate adenocarcinoma In vitro and in vivo N/A Angiogenesis↓
Tumor progression↓
ROS↓
VEGF↓
[40]
hMenSCs Hamster buccal pouch carcinoma In vitro and in vivo N/A Endothelial cell apoptosis↑
Tumor progression↓
VEGF↓ [41]
hBMSCs Hepatocellular carcinoma; ovarian cancer; Kaposi’s sarcoma In vitro and in vivo N/A Tumor progression↓ Activation of negative regulators of cell cycle [42]
hUCMSCs Bladder carcinoma In vitro and in vivo N/A Proliferation↓
Apoptosis↑
Phosphorylation of Akt protein kinase↓
p53/p21 and Caspase 3↑
[43]
hAMSCs Ovarian cancer In vitro miRNAs Proliferation↓ Activation of mitochondria-mediated apoptosis signaling [44]
hAMSCs Metastatic prostate cancer In vitro and in vivo miR-145 Proliferation↓
Apoptosis↑
BclxL↓ [45]
hBMSCs Lung cancer In vitro and in vivo let-7i Proliferation↓
Metastasis↓
KDM3A↓
DCLK1↑
FXYD3↓
[46]
hBMSCs Nasopharyngeal carcinoma In vitro and in vivo N/A Proliferation↑
Migration↑
Tumorigenesis↑
FGF19-FGFR4 dependent ERK signaling cascade; EMT [47]
hBMSCs Osteosarcoma In vitro and in vivo lncRNA PVT1 Tumor growth↑
Metastasis↑
Stabilize ERG and sponge miR-183-5p [48]
hUCMSCs Renal cancer In vitro and in vivo HGF mRNA Tumor growth↑
Aggressiveness↑
Activation of AKT and ERK1/2 signaling [49]
hUCMSCs Lung adenocarcinoma cancer In vitro and in vivo miR-410 Proliferation↑
Apoptosis↓
PTEN↓ [50]
hUCMSCs Lung cancer In vitro and in vivo miR-130b-3p Proliferation↑
Migration and invasion↑
Apoptosis↓
FOXO3↓
Activation of NFE2L2/TXNRD1 pathway
[51]
hUCMSCs Breast cancer In vitro N/A Proliferation↑
Migration and invasion↑
Induction of EMT via the ERK pathway [52]
hBMSCs Non-small cell lung cancer In vitro and in vivo Increased miR-21-5p Tumor growth↑
Proliferation↑
Invasion↑
Macrophage M2 Polarization [53]
hBMSCs of patients with multiple myeloma Multiple myeloma In vitro and in vivo Lower miR-15a Tumor growth↑
Dissemination↑
Oncogenic proteins, cytokines, and adhesion molecules↑ [54]
p53 deficient mBMSCs Mouse gastric cancer In vitro and in vivo UBR2 Tumor growth↑
Metastasis↑
Stemness↑
Abnormal activation of Wnt/β‐catenin signaling pathway [55]
hBMSCs Bone marrow–metastatic breast cancer In vitro and in vivo miR-23b Proliferation and invasion↓
Sensitivity to docetaxel↓
Dormancy↑
MARCKS↓ [60]
hBMSCs Breast carcinoma In vitro N/A Proliferation and migration↓
Dormancy↑
Anti-cancer drug resistance↑
MET [61]
hUCMSCs Breast cancer; ovarian cancer In vitro N/A Tumor heterogeneity↑
Dormancy↑
Tumor cell resistance↑
Induction of MMP-2 and ecto-5′-nucleotidase activity [62]
hUCMSCs Gastric cancer In vitro and in vivo Proteins Drug resistance↑ CaM-Ks/Raf/MEK/ERK signaling cascade↑ [63]
  1. EV extracellular vesicle, hAMSCs human adipose mesenchymal stem cells, hBMSCs human bone marrow mesenchymal stem cells, hMenSCs human menstrual stem cells, hUCMSCs human umbilical cord mesenchymal stem cells, mBMSCs mouse bone marrow mesenchymal stem cells, MSC mesenchymal stem cell