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Table 4 Applications of bioengineered MSC-derived EVs in cancer

From: Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

EV source Cancer Method Modification Effect Proposed mechanism References
hBMSCs Breast cancer In vivo Loaded miR-379 Tumor growth↓ Regulate COX-2 [103]
rBMSCs Primary rat astrocytes and glioma In vivo Loaded miR-146 Tumor growth↓ EGFR↓
NF-κB↓
[104]
hBMSCs Glioma In vitro and in vivo Loaded miR-124a Tumor growth↓ FOXA2↓
FOXA2-mediated aberrant intracellular lipid accumulation↑
[105]
hBMSCs Glioblastoma In vitro and in vivo Loaded miR-34a Proliferation, migration and tumorigenesis↓
Chemosensitivity to TMZ↑
MYCN↓ [106]
hBMSCs Colorectal cancer In vitro and in vivo Loaded miR‐16‐5p Proliferation, migration, and invasion↓
Apoptosis↑
ITGA2↓ [107]
hBMSCs Androgen-dependent prostate cancer In vitro and in vivo Loaded miR-205 Proliferation, migration, and invasion↓
Apoptosis↑
RHPN2↓ [108]
hUCMSCs Breast cancer In vitro and in vivo Loaded miR-148b-3p Proliferation, migration, and invasion↓
Apoptosis↑
TRIM59↓
EMT↓
[109]
hUCMSCs Endometrial cancer In vitro Loaded miR-302a Proliferation↓
Migration↓
Cyclin D1 ↓
AKT signaling pathway↓
[110]
hBMSCs Pancreatic cancer In vitro and in vivo Loaded miR-126-3p Proliferation, migration, and invasion↓
Apoptosis↑
ADAM9↓ [111]
hBMSCs Osteosarcoma In vitro and in vivo Loaded miR-206 Proliferation, migration, and invasion↓
Apoptosis↑
Target TRA2B [112]
hBMSCs Cervical cancer In vitro and in vivo Loaded miR-144-3p Proliferation, migration, and invasion↓
Apoptosis↑
CEP55↓ [113]
hBMSCs Ovarian cancer In vitro and in vivo Loaded miR-424 Proliferation, migration, and invasion↓
Tube formation↓
MYB↓ [114]
hBMSCs Osteosarcoma In vitro Loaded miR-143 Migration↓ N/A [115]
hBMSCs Gastric cancer In vitro Loaded miR-221 Migration, invasion, and adhesion to the matrix↑ N/A [116]
hAMSCs Osteosarcoma In vitro and in vivo Loaded miR-101 Migration↓ BCL6↓ [117]
hBMSCs Breast cancer In vitro and in vivo Loaded LNA-anti-miR-142-3p Apoptosis↑
Tumor growth↓
miR-142-3p↓
miR-150↓
associated tumor suppressor genes including APC and P2X7R↑
[118]
hBMSCs Pancreatic cancer with KrasG12D mutation In vitro and in vivo Loaded KRASG12D siRNA Tumor growth↓ CD47-mediated protection; RAS-mediated micropinocytosis [119]
hBMSCs Pancreatic cancer In vitro and in vivo iEXO-OXA Tumor growth↓ Tumor-suppressive macrophage polarization, cytotoxic T lymphocytes recruitment and Tregs downregulation [120]
hAMSCs, hBMSCs, hMenSCs, DPMSCs, hUCMSCs Prostate tumor; breast adenocarcinoma; Rat glioblastoma In vitro and in vivo Loaded mRNA Apoptosis↑ Intracellular conversion of 5-FC to 5-FU [121]
mBMSCs Pancreatic adenocarcinoma In vitro and in vivo Loaded Taxol Tumor growth↓ N/A [122]
hUCMSCs Breast cancer; ovarian cancer; lung carcinoma In vitro and in vivo Loaded Taxol Efficient targeting↑
Tumor growth↓
Metastases↓
N/A [123]
hGinPaMSCs Pancreatic adenocarcinoma; glioblastoma; mesothelioma; squamous cell carcinoma In Vitro Loaded PTX Tumor growth↓ N/A [124]
mBMSCs Mouse colon adenocarcinoma in Vitro and in vivo DOX@exosome-apt Tumor growth↓ N/A [125]
MSCs Lung cancer; malignant pleural mesothelioma; renal cancer; breast adenocarcinoma; neuroblastoma In vitro TRAIL Apoptosis↑
Sensitivity to TRAIL↑
N/A [126]
MSCs Melanoma; breast adenocarcinoma; lung carcinoma; colon adenocarcinoma In vitro and in vivo CTNF-α-exosome-SPIONs Efficient targeting under an external magnetic field↑
Tumor growth↓
Toxicity↓
Induction of the TNFR I-mediated apoptotic pathway [127]
hAMSCs Hepatocellular carcinoma In vitro and in vivo Loaded miR-199a Sensitivity to doxorubicin↑ mTOR pathway↓ [128]
hAMSCs Hepatocellular carcinoma In vitro and in vivo Loaded miR-122 Chemosensitivity↑ Apoptosis and cell cycle arrest↑ [129]
hBMSCs Glioblastoma multiforme In vitro Loaded anti-miR-9 Sensitivity to TMZ↑ Reverse the expression of the multidrug transporter [130]
hBMSCs Breast cancer In vitro and in vivo Loaded antagomiR222/223 Chemosensitivity↑
Dormancy↓
Regulate cycling quiescence [131]
hAMSCs Anaplastic thyroid cancer In vitro Loaded TKI Radioiodine‐sensitivity↑ Thyroid‐specific proteins and transcription factors↑ [132]
  1. DPMSCs dental pulp mesenchymal stem cells, EV extracellular vesicle, hAMSCs human adipose mesenchymal stem cells, hBMSCs human bone marrow mesenchymal stem cells, hGinPaMSCs human gingival papilla mesenchymal stem cells, hMenSCs human menstrual stem cells, hUCMSCs human umbilical cord mesenchymal stem cells, mBMSCs mouse bone marrow mesenchymal stem cells, MSC mesenchymal stem cell, rBMSCs rat bone marrow mesenchymal stem cells