Table 5 Registered clinical trials involving MSC-derived EVs
From: Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
Identifier | Disease | EV source | Key cargo | Status | Year of registration |
|---|---|---|---|---|---|
NCT03384433 | Acute ischemic stroke | MSCs | miR-124 | Recruiting | 2017 |
NCT03437759 | Macular holes | UCMSCs | N/A | Active, not recruiting | 2018 |
NCT03608631 | Metastatic pancreas cancer with KrasG12D mutation | BMSCs | KRASG12D siRNA | Recruiting | 2018 |
NCT03857841 | Bronchopulmonary Dysplasia | BMSCs | N/A | Active, not recruiting | 2019 |
NCT04134676 | Chronic Ulcer | WJ-MSCs | N/A | Completed | 2019 |
NCT04173650 | Dystrophic Epidermolysis Bullosa | BMSCs | N/A | Not yet recruiting | 2019 |
NCT04213248 | Dry eye related to cGVHD | UCMSCs | N/A | Recruiting | 2019 |
NCT04223622 | Osteoarthritis | AMSCs | N/A | Not yet recruiting | 2020 |
NCT04276987 | Severe novel coronavirus pneumonia | AMSCs | N/A | Completed | 2020 |
NCT04356300 | MODS after surgical repaire of ATAAD | UCMSCs | N/A | Not yet recruiting | 2020 |
NCT04388982 | Alzheimer's Disease | AMSCs | N/A | Recruiting | 2020 |
NCT04491240 | SARS-CoV-2 Associated Pneumonia | MSCs | N/A | Completed | 2020 |
NCT04544215 | Carbapenem-resistant gram-negative bacilli-induced pulmonary infection | AMSCs | N/A | Recruiting | 2020 |
NCT04602104 | ARDS | MSCs | N/A | Not yet recruiting | 2020 |
NCT04602442 | COVID-19 Associated Pneumonia | MSCs | N/A | Enrolling by invitation | 2020 |
NCT04657458 | COVID-19 associated ARDS | BMSCs | N/A | Available | 2020 |
NCT04798716 | ARDS or NCP caused by COVID-19 | MSCs | N/A | Not yet recruiting | 2021 |