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Table 5 Registered clinical trials involving MSC-derived EVs

From: Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Identifier Disease EV source Key cargo Status Year of registration
NCT03384433 Acute ischemic stroke MSCs miR-124 Recruiting 2017
NCT03437759 Macular holes UCMSCs N/A Active, not recruiting 2018
NCT03608631 Metastatic pancreas cancer with KrasG12D mutation BMSCs KRASG12D siRNA Recruiting 2018
NCT03857841 Bronchopulmonary Dysplasia BMSCs N/A Active, not recruiting 2019
NCT04134676 Chronic Ulcer WJ-MSCs N/A Completed 2019
NCT04173650 Dystrophic Epidermolysis Bullosa BMSCs N/A Not yet recruiting 2019
NCT04213248 Dry eye related to cGVHD UCMSCs N/A Recruiting 2019
NCT04223622 Osteoarthritis AMSCs N/A Not yet recruiting 2020
NCT04276987 Severe novel coronavirus pneumonia AMSCs N/A Completed 2020
NCT04356300 MODS after surgical repaire of ATAAD UCMSCs N/A Not yet recruiting 2020
NCT04388982 Alzheimer's Disease AMSCs N/A Recruiting 2020
NCT04491240 SARS-CoV-2 Associated Pneumonia MSCs N/A Completed 2020
NCT04544215 Carbapenem-resistant gram-negative bacilli-induced pulmonary infection AMSCs N/A Recruiting 2020
NCT04602104 ARDS MSCs N/A Not yet recruiting 2020
NCT04602442 COVID-19 Associated Pneumonia MSCs N/A Enrolling by invitation 2020
NCT04657458 COVID-19 associated ARDS BMSCs N/A Available 2020
NCT04798716 ARDS or NCP caused by COVID-19 MSCs N/A Not yet recruiting 2021
  1. AMSCs adipose mesenchymal stem cells, ARDS acute respiratory distress syndrome, ATAAD acute type A aortic dissection, BMSCs bone marrow mesenchymal stem cells, cGVHD chronic graft versus host diseases, EV extracellular vesicle, MODS multiple organ dysfunction syndrome, MSC mesenchymal stem cell, NCP novel coronavirus pneumonia, UCMSCs umbilical cord mesenchymal stem cells, WJ-MSCs Wharton's Jelly mesenchymal stem cells