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Table 1 Overview of dysregulated circRNAs in hepatocellular carcinoma (HCC)

From: Circular RNAs: characteristics, biogenesis, mechanisms and functions in liver cancer

circRNAs Dysregulation Sponge targets Downstream genes/proteins Phenotype References
circCDYL Up miR-892a
miR-328-3p
HDGF/HIF1AN Proliferation (+) [39]
circSLC3A2 Up miR-490-3p PPM1F Proliferation (+) [40]
circFBLIM1 Up miR-346 FBLIM1 Proliferation (+) [41]
circHIPK3 Up miR-124 AQP3 Proliferation (+) [42]
circZNF566 Up miR-4738-3p TDO2 Proliferation (+) [43]
circMAT2B Up miR-338-3p PKM2 Proliferation (+);
Metastasis (+)
[44]
circASAP1 Up miR-326
miR-532-5p
MAPK1
CSF-1
Proliferation (+);
Metastasis (+)
[37]
circDYNC1H1 Up miR-140-5p SULT2B1 Proliferation (+) [45]
circARFGEF2 Up miR-143-3p
PCBP1
FOSL2
CD44v6
Proliferation (+);
Metastasis (+)
[46]
circMAST1 Up miR-1299 CTNND1 Proliferation (+) [47]
circBACH1 Up p27
HuR
Proliferation (+) [48]
circRHOT1 Up TIP60
NR2F6
Proliferation (+);
Metastasis (+)
[49]
circβ-catenin Up β-catenin-370aa
(circβ-catenin’s translation product)
Proliferation (+);
Metastasis (+)
[50]
circUHRF1 Up miR-449c-5p TIM-3 Proliferation (+);
Metastasis (+);
Drug resistance (+);
Immunity (−)
[51]
circSORE Up miR-103a-2-5p
miR-660-3p
Wnt2b Drug resistance (+) [52]
circSORE Up YBX1 Drug resistance (+) [53]
circMET Up miR-30-5p CXCL10 Drug resistance (+);
Immunity (−)
[54]
circUBAP2 Up miR-194-3p MMP9 Proliferation (+);
Metastasis (+)
[59]
circPABPC1 Down ITGB1 Proliferation (−);
Metastasis (−)
[60]
circADD3 Down EZH2
CDK1
Proliferation (−);
Metastasis (−)
[55]
circMTO1 Down miR-9 P21 Proliferation (−) [56]
circSETD3 Down miR-421 MAPK14 Proliferation (−) [57]
circSMARCA5 Down miR-17-3p
miR-181b-5p
TIMP3 Proliferation (−) [36]
circZKSCAN1 Down FMRP
CCAR1
Proliferation (−);
Metastasis (−)
[58]