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Table 2 Diagnostic significance of sEV-derived ncRNAs in PDAC

From: Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications

Reference

Sample

sEV isolation

Normalization

ncRNA (expression in PC)

Patients enrolled

Diagnostic accuracy (AUC) (PC vs. non-PC if not stated otherwise)

(↑)

(↓)

Que et al. [142]

Serum

UC

RNU6B

miR-17-5p

miR-21

–

22 PDAC, 6 BPT, 7 AC, 6 CP, 8 HC

0.887 (miR-17-5p)

0.897 (miR-21)

Madhavan et al. [156]

Serum

DGUC

RNU6, SNORD43

18S & 5S rRNA

miRs 1246, 4644, 3976, 4306

–

112 PDAC, 11 other PC, 22 BPT, 23 CP, 18 HC

Not assessed

Machida et al. [158]

Saliva

TEI

RNU6

miR-1246

miR-4644

–

12 PBC (thereof 9 PDAC), 13 HC

0.814 (miR-1246), 0.763 (miR-4644)

0.833 (miRs 1246 + 4644)

Lai et al. [146]

Plasma

UC

miR-425-5p

miRs 10b, 20a, 21, 30c, 106b, 181a

miRs let7a, 122

29 PDAC, 11 CP, 6 HC

1.00 (miRs 10b, 21, 30c, 181a, let7a)

0.99 (miR-122), 0.95 (miR-20a), 0.85 (miR-106b)

Chen et al. [229]

Serum

UC

5S rRNA

miR-23b-3p

–

16 PDAC, 20 HC

1.00 (miR-23-3p)

Xu et al. [157]

Plasma

EQ

cel-miR-54

miR-1246

miR-196a

miR-196b (n.s.)

–

15 PC (UICC I-IIa)

15 HC

0.73 (miR-1246)

0.81 (miR-196a)

0.71 (miR-196b)

Goto et al. [145]

Serum

EQ

not specified

miRs 21, 191, 451a

–

32 PC, 22 HC

0.826 (miR-21), 0.788 (miR-191)

0.759 (miR-451a)

Zhou et al. [152]

Plasma

EQ

miR-103a

miR-122-5p,

miR-193b-3p

miR-221-3p

31 PC, 37 HC

0.772 (miR-122-5p), 0.651 (miR-193b-3p)

0.849 (miRs 122-5p + 193b-3p)

Kitagawa et al. [162]

Plasma

not specified

not specified

SNORA74A, SNORA25, SNORA22, SNORA14B, SNORD22

–

27 PDAC, 13 HC

0.909 (SNORA74A)

0.903 (SNORA25)

0.883 (SNORA22)

0.875 (SNORA14B)

0.862 (SNORD22)

Nakamura et al. [160]

PJ

UC

miR-16

miR-21

miR-155

–

27 PDAC, 8 CP

0.83 (miR-21)

0.89 (miR-155)

0.91 (miR-21 + miR-155)

Zou et al. [230]

Serum

EQ

cel-miR-39

miRs 19a, 19b, 192

–

32 PC, 32 HC

Not assessed

Shang et al. [204]

Plasma

UC

RNU6

–

miR-1231

32 PC, 20 HC

Not assessed

Sun et al. [76]

Plasma

UC

not specified

miR-3607-3p

–

40 PC, 20 HC

Not assessed

Takahashi et al. [55]

Serum

EQ

RNU6B

lncHULC

–

20 PDAC, 22 IPMN,

21 HC

0.92

Reese et al. [155]

Serum

UC

cel-miR-39

miRs 200b, 200c

–

56 PDAC, 11 CP, 22 HC

0.77 (miR-200b TSE) 0.68 (miR-200c TSE)

0.97 (4-miR-panel + CA.19-9)

Pu et al. [151]

Plasma

TEI

n/a *

miR-10b, miR-21

–

36 PC, 65 HC

0.6543 (miR-10b)

0.7171 (miR-21)

0.791 (miR-10b + miR-21)

Yoshizawa et al. [159]

Urine

EQ

miR-8069

ratio of miRs 3940-5p/8069

–

43 PDAC, 12 CP, 25 HC

0.732

Yang et al. [167]

Plasma

TENPO

not specified

miR-409

–

57 PDAC, 49 HC, 12 CP, 3 IPMN, 12 BPT, 3 others

0.95 (5-marker-panel including miR-409,

2 mRNAs, ccfDNA, and CA.19-9)

Flammang et al. [231]

Serum

UC

cel-miR-39

miR-192-5p

–

44 PDAC, 11 CP, 12 HC

0.83 (PDAC vs. HC)

0.54 (PDAC vs. CP)

Wu et al. [144]

Serum

EQ

cel-miR-39

miR-21, miR-210

–

30 PC, 10 CP

0.83 (miR-21), 0.85 (miR-210)

0.90 (miR-21 + miR-210)

0.9 (miR-21 + CA-19-9)

0.9 (miR-210 + CA.19.9)

Guo et al. [116]

Serum

EQ

β-actin

lncUCA1

–

46 PC, 16 HC

0.7813

Zhou et al. [150]

Plasma

MC

CD81

miRs 10b, 21, 451a

–

30 PC, 10 CP

0.875 (miR-10b)

0.939 (miR-21)

0.930 (miR-451a)

1.00 (miRs 10b + 21 + 451a + EphA2)

Cao et al. [107]

Plasma

TEI

cel-miR-39

miR-616

miR-4465

–

50 PC, 30 HC

Not assessed

Wang et al. [232]

Serum

EEM

RNU6B

–

miR-1226

17 PDAC, 12 BPD

0.74 (PDAC vs. BPD)

Shao et al. [154]

Serum

EQ

cel-miR-39

miR-483-3p

–

63 PDAC, 22 HC

0.69 (sEV miR-483-3p)

0.84 (serum + sEV miR-483-3p)

Han et al. [115]

Plasma

EQ

RNU6

lncCCAT1

–

93 PC, 93 HC

not assessed

  1. AC, ampullary carcinoma; AUC, area under the receiver operating characteristic curve; BPT, benign pancreatic tumor; cel, caenorhabditis elegans; ccfDNA, circulating cell-free DNA; CP, chronic pancreatitis; DGUC, density gradient ultracentrifugation; EEM, ExoEasy Maxi Kit (Qiagen); EQ, ExoQuick Exosome Isolation Kit (System Biosciences); HC, healthy control; MC, microfluidic chip; mRNA, messenger RNA; other PC, non-PDAC pancreatic cancer; n.s., not significant; PanNET, pancreatic neuroendocrine tumor; PBC, pancreatobiliary cancer; PC, pancreatic cancer (all entities); PDAC, pancreatic ductal adenocarcinoma; PJ, pancreatic juice; TEI, Total Exosome Isolation Kit (ThermoFisher); TENPO, track etched magnetic nanopore device; UC, ultracentrifugation
  2. *Pu et al. utilized a tethered cationic lipoplex nanoparticles biochip for direct and absolute quantification of sEV microRNA, obviating the need for normalization