Fig. 10

Schematic diagram showing the synergistic effect between Mn²⁺ and YM101. On the one hand, Mn²⁺ promoted dendritic cell (DC) maturation. On the other hand, YM101 restrained cancer-associated fibroblast (CAF) activity, enhanced T cell infiltration and restored T cell from exhaustion. The effects of Mn²⁺ and YM101 were independent and complementary, and the combination therapy had a potent and broad-spectrum antitumor effect