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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response

Fig. 4

The effects of monocyte depletion on BsAb directed T cell trafficking and in vivo anti-tumor response. A Luciferase transduced T cells [Luc(+) T cells] or Luciferase transduced GD2-BsAb armed T cells [Luc(+) GD2-EATs] were administered with anti-Ly6C antibody to the mice bearing neuroblastoma patient-derived xenograft (PDX). B Bioluminescence in the lesions of tumor was monitored. The bioluminescence images on day 7 and quantification of the bioluminescence in the lesions of tumor. C In vivo anti-tumor response by GD2-EATs with anti-Ly6C antibody was tested against neuroblastoma PDXs. D In vivo anti-tumor effect of GD2-EATs with anti-Ly6C antibody was tested against osteosarcoma PDXs, and long-term survival was analyzed

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