Table 3 Common recurrent somatic mutations of prognostic significance [70,71,72]
From: Prognostic and predictive biomarker developments in multiple myeloma
Pathway | % with affected pathway | Gene name | Frequency (%) | Prognosis |
|---|---|---|---|---|
MAPK | 40 | KRAS | 23 | Intermediate |
BRAF | 20 | |||
NRAS | 8 | |||
NF-κB | 20 | TRAF | 3 | Intermediate |
CYLD | 2 | |||
LTB | 3 | |||
DNA repair | 10 | TP53 | 9 | Poor |
ATM | 3 | |||
ATR | 1 | |||
RNA metabolism | 15 | FAM463 | 9 | Intermediate |
DIS3 | 7 | |||
Plasma cell differentiation | 10 | IRF4 | 3 | Favourable |
EGR1 | 5 |