Fig. 4From: SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cellsSIRPα-αCD123 fusion antibodies stimulate phagocytosis of AML patient cells by allogeneic and autologous macrophages. AML target cells and macrophages were incubated with 50 nM antibody for 3 h at an E:T ratio of 1:1. ADCP was measured as the percentage of double-positive cells (gated) from all macrophages. Each symbol represents one patient (Table 1). A Phagocytosis of AML patient cells by allogeneic macrophages (n = 4). B Phagocytosis of AML patient cells by autologous macrophages (n = 10). Statistical differences were determined by one-way ANOVA using Holm-Sidak's post hoc test. *p < 0.05, ****p < 0.0001, not significant (ns)Back to article page