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Table 9 Classification of cancer vaccine antigens

From: Combination strategies to maximize the benefits of cancer immunotherapy

Category

subcategory

Tumor specificity

Immune tolerance

Prevalence

Potential for cancer vaccine

Cancer-associated antigens

Cancer/testis antigens

Usually high

Low

Intermediate

Intermediate

Overexpressed and differentiation antigens

Variable, but usually low

High

High

Low

Cancer-unique antigens

Cancer viral antigens

High

Low

Intermediate

High

Neoantigens

High

Low

Low and usually unique

High