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Table 9 Classification of cancer vaccine antigens

From: Combination strategies to maximize the benefits of cancer immunotherapy

Category subcategory Tumor specificity Immune tolerance Prevalence Potential for cancer vaccine
Cancer-associated antigens Cancer/testis antigens Usually high Low Intermediate Intermediate
Overexpressed and differentiation antigens Variable, but usually low High High Low
Cancer-unique antigens Cancer viral antigens High Low Intermediate High
Neoantigens High Low Low and usually unique High