From: Combination strategies to maximize the benefits of cancer immunotherapy
Category | subcategory | Tumor specificity | Immune tolerance | Prevalence | Potential for cancer vaccine |
---|---|---|---|---|---|
Cancer-associated antigens | Cancer/testis antigens | Usually high | Low | Intermediate | Intermediate |
Overexpressed and differentiation antigens | Variable, but usually low | High | High | Low | |
Cancer-unique antigens | Cancer viral antigens | High | Low | Intermediate | High |
Neoantigens | High | Low | Low and usually unique | High |