Skip to main content
Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Targeting mutant p53 for cancer therapy: direct and indirect strategies

Fig. 1

The functions of p53 in the normal cells. p53 is an important tumor suppressor in normal cells to maintain homeostasis. Throughout their lifespan, cells are faced with continuing stresses including endogenous and exogenous stresses. To overcome these stresses, p53 is activated to mediate a series of cellular responses via its transcription-dependent functions or direct protein-to-protein interactions. p53-mediated responses also rely on the type and degree of insults, as well as the cell types and the context in which the insult occurs

Back to article page