Table 5 Noncoding RNAs regulated by mutp53
From: Targeting mutant p53 for cancer therapy: direct and indirect strategies
Target | Mechanism | Cancer type | References |
|---|---|---|---|
miR-130b | miR-130b promotes EMT by ZEB1 | Endometrial cancer | [179] |
miR-30d | miR-30d impacts on the sector to promote ECM for metastasis | Breast cancer | [124] |
miR-21-3p/miR-769-3p | p53 R273H activates fibroblasts by exosomal miR-21-3p | Lung cancer | [113] |
miR-1246 | Cancers with mutp53 shed exosomes containing miR-1246 induce a miR-1246-dependent reprogram of TAMs to a tumor-suppurative status | Colon cancer | [180] |
miR-34 | This tumor-suppressive miRNA is usually downregulated in p53-mutated cancers | Multiple cancers | |
miR-223-3p | Mutp53 directly binds to the promoter region of miR-223-3p that can suppress tumor proliferation and migration | Lung cancer | [123] |
miR-200 | miR-200 suppressed by mutp53 losses the ability to inhibit metastasis | NSCLC | [182] |
Let-7i | let-7i inhibits invasion and metastasis by repressing E2F5, LIN28B, MYC, and NRAS | Breast cancer | [52] |
miR-142-3p | Upregulation of Dnmt1 promotes miR-142-3p hypermethylation of its locus | Pancreatic ductal adenocarcinoma | [183] |
LincRNA-p21 | LincRNA-p21 cannot be activated by mutp53 in response to DNA damage | HNSCC | [137] |
AGPG | p53 mutations lose the transcriptionally suppress function to inhibit AGPG expression, and upregulated AGPG stabilizes PFKFB3 to promote glycolysis | Esophageal squamous cell carcinoma | [90] |
MALAT1 | MALAT1 acts as a bridge between mutp53 and ID4 to modulate VEGFA isoforms expression | Breast cancer | [138] |
Lnc273-31/34 | p53 R273H specific upregulates lnc273-31 to maintain self-renew of colorectal CSCs | Colorectal cancer | [184] |
lncMIR205HG | Mutp53 recruited by NF-YA and E2F1 to the promoter of MIR205HG to upregulate lncMIR205HG to promote cancer progression | HNSCC | [185] |
LINC00460 | Upregulation of LINC00460 by mutp53 increases mutp53 levels through competitively binding to miRNAs targeting mutp53 | Colorectal cancer | [186] |
CircPVT1 | CircPVT1 is upregulated by mutp53 in HNSCC patients to promote cancer proliferation by miR-497-5p | HNSCC | [187] |
Circ-CCNB1 | Circ-CCNB1 is suppressed in p53-mutated cancer, and expression of circ-CCNB1 activates the H2AX-dependent tumor suppressor Bclaf1 only in cancer cells harboring mutp53 | Breast cancer | [140] |