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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer

Fig. 2

The performance of the cancer cell fraction model in gastric cancer patients. a Clinical and histopathologic parameters, somatic mutations and cancer cell fraction for all patients. Top panel, summary of the frequencies of the tracked mutations in tumor and matched PLF samples from 104 patients. Blue bar, the tumor frequency of each tracked mutation. Frequency values are shown on the left vertical axis. Red bar, the detected peritoneal lavage fluid frequency of each tracked mutation. Frequency values are shown on the right vertical axis. The clinical outcome of patients is indicated under the bar. Middle panel, the cancer cell fraction of each patient. Bottom panel, clinical and histopathological characteristics. b The distribution of the cancer cell fraction in patients with peritoneal dissemination (n = 27), lymphatic metastasis (n = 6) or no recurrence (n = 71). Reported p values were computed using a 2-tailed Wilcoxon Mann–Whitney U test. ***p < 0.001; *p < 0.05. c Binary results of the PLF mutation profiling model and clinical risk factors. Pathologic diagnosis was defined as high (pT4) or low (pT0–3) according to the standard criteria. PD, peritoneal dissemination; PPV, positive predictive value; NPV, negative predictive value. d The Kaplan–Meier survival analysis shows the probability of recurrence-free survival as determined by MRD analysis of PLF (n = 98). e Kaplan–Meier estimates of overall survival for 104 gastric cancer patients based on MRD analysis of PLF. f The Kaplan–Meier survival analysis shows the probability of recurrence-free survival (RFS) as determined by MRD analysis of PLF in stage pT4 patients (n = 56) (for peritoneal dissemination). Shaded areas in the Kaplan–Meier plots indicate 95% CIs. HR: hazard ratio; CCF: cancer cell fraction

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