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Table 4 Overall mortality rate by disease and treatment received

From: COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

 

Overall mortality

 

Survived n (%)

Died n (%)

Baseline hematological malignancies

Acute lymphoid leukemia

125 (74)

44 (26)

Chronic lymphoid leukemia

340 (71.7)

134 (28.3)

Acute myeloid leukemia

298 (60)

199 (40)

Chronic myeloid leukemia

144 (89.5)

17 (10.5)

Myelodysplastic syndrome

161 (57.7)

118 (42.3)

 Low-intermediate risk

77 (55.8)

61 (44.2)

 High risk

26 (54.2)

22 (45.8)

 Not stated

58 (62.4)

35 (37.6)

Hairy cell leukemia

15 (65.2)

8 (34.8)

Hodgkin lymphoma

120 (88.9)

15 (11.1)

Non-Hodgkin lymphoma

739 (68.2)

345 (31.8)

 Indolent

354 (71.3)

143 (28.7)

 Aggressive

337 (65.3)

179 (34.7)

 Not stated

48 (67.6)

23 (32.4)

Essential thrombocythemia

57 (82.6)

12 (17.4)

Myelofibrosis

77 (63.1)

45 (36.9)

Polycythemia vera

56 (80)

14 (20)

Systemic mastocytosis

5 (83.4)

1 (16.6)

Multiple Myeloma

458 (67)

226 (33)

Amyloidosis

7 (87.5)

1 (12.5)

Aplastic anemia

14 (70)

6 (30)

Last/ongoing treatment strategy before COVID-19

Anagrelide/Hydroxyurea

106 (73.1)

39 (26.9)

Conventional chemotherapy

423 (70.9)

174 (29.1)

Hypomethylating agents

58 (41.2)

83 (58.8)

Immunotherapy only

89 (71.2)

36 (28.8)

Immunochemotherapy

595 (69.4)

262 (30.6)

Immunomodulators

139 (63.8)

79 (36.2)

Targeted therapya

453 (74.6)

154 (25.4)

Allogeneic HSCT

130 (75.2)

43 (24.8)

Autologous HSCT

54 (73)

20 (27)

CAR-T

11 (52.4)

10 (47.6)

Radiotherapy

9 (90)

1 (10)

Palliative/supportive measures

122 (56)

104 (46)

Other

17 (60.7)

11 (39.3)

Unknown

28 (68.3)

13 (31.7)

No treatment

382 (71)

156 (29)

  1. HSCT Hematopoietic stem cell transplantation, CAR-T chimeric antigen receptor T-cell therapies
  2. aBortezomib, ibrutinib, idelalisib, ruxolitinib, TKI (tyrosine kinase inhibitors) and venetoclax