Table 5 Overall mortality predictors in COVID-19 HM patients

Sex

Female

–

–

–

–

–

–

Male

0.059

1.119

0.095–1.258

0.376

1.065

0.927–1.223

Age

 < 0.0001

1.036

1.031–1.041

 < 0.0001

1.032

1.026–1.039

Malignancy status

Controlled disease

–

–

–

–

–

–

Active disease

 < 0.0001

2.107

1.863–2.383

 < 0.0001

1.860

1.615–2.141

Unknown

 < 0.0001

2.293

1.607–3.274

 < 0.0001

2.353

1.538–3.601

Hematological malignancy

Hodgkin lymphoma

–

–

–

–

–

–

Chronic lymphoid leukemia

 < 0.0001

2.789

1.635–4.757

0.763

1.093

0.614–1.947

Acute myeloid leukemia

 < 0.0001

4.364

2.581–7.376

0.011

2.046

1.176–3.557

Chronic myeloid leukemia

0.915

0.963

0.481–1.928

0.086

0.513

0.239–1.099

Acute lymphoblastic leukemia

0.002

2.530

1.405–4.553

0.250

1.457

0.767–2.768

Non-Hodgkin lymphoma

 < 0.0001

3.041

1.814–5.100

0.569

1.171

0.68–2.015

Aplastic anemia

0.040

2.695

1.045–6.948

0.179

2.022

0.724–5.645

Essential thrombocythemia

0.234

1.585

0.742–3.387

0.332

0.667

0.295–1.511

Multiple myeloma

 < 0.0001

3.355

1.989–5.658

0.630

1.145

0.661–1.984

Myelodysplastic syndrome

 < 0.0001

4.627

2.704–7.919

0.072

1.706

0.953–3.056

Myelofibrosis

 < 0.0001

3.786

2.110–6.791

0.185

1.540

0.813–2.915

Polycythemia vera

0.059

2.016

0.973–4.176

0.985

0.992

0.456–2.158

Amyloidosis

0.893

1.150

0.152–8.705

0.932

-

-

Hairy cell leukemia

0.019

2.936

1.197–7.202

0.301

1.806

0.589–5.533

Systemic mastocytosis

0.715

1.457

0.192–11.031

0.968

0.959

0.126–7.323

COVID-19 infection

Asymptomatic

–

–

–

–

–

–

Mild infection

0.545

1.087

0.830–1.422

0.653

1.074

0.786–1.467

Severe infection

 < 0.0001

2.127

1.722–2.628

 < 0.0001

1.682

1.312–2.157

Critical infection

 < 0.0001

5.333

4.300–6.613

 < 0.0001

4.230

3.294–5.432

Unknown

0.623

1.229

0.540–2.800

0.928

–

–

Chronic cardiopathy

 < 0.0001

2.011

1.792–2.257

 < 0.0001

1.406

1.218–1.624

Liver disease

0.008

1.394

1.091–1.781

0.020

1.388

1.052–1.831

Chronic pulmonary disease

 < 0.0001

1.516

1.320–1.740

0.926

1.008

0.85–1.195

Diabetes mellitus

 < 0.0001

1.352

1.172–1.560

0.439

1.070

0.901–1.272

Obesity

0.796

0.974

0.796–1.191

–

–

–

Renal impairment

 < 0.0001

1.883

1.589–2.232

 < 0.0001

1.404

1.143–1.724

Smoking history

0.013

1.224

1.043–1.436

0.031

1.223

1.019–1.469

Neutrophils, cells/mm³

≤ 0.5 × 10⁹/mm³

–

–

–

–

–

–

0.501-0.999 × 10⁹/mm³

 < 0.0001

0.594

0.450–0.785

0.272

0.845

0.626–1.141

 ≥ 1 × 10⁹/mm³

 < 0.0001

0.514

0.431–0.614

0.184

0.862

0.693–1.073

Lymphocytes, cells/mm³

≤ 0.2 × 10⁹/mm³

–

–

–

–

–

–

0.201-0.499 × 10⁹/mm³

0.004

0.746

0.611–0.912

0.021

0.779

0.629–0.963

 ≥ 0.5 × 10⁹/mm³

 < 0.0001

0.499

0.422–0.590

 < 0.0001

0.601

0.499–0.722

Last chemotherapy

 > 3 months before COVID-19

–

–

–

–

–

–

In the last 3 months

 < 0.0001

1.531

1.226–1.912

0.081

1.236

0.974–1.568

In the last month

 < 0.0001

1.688

1.408–2.024

0.657

1.047

0.854–1.284

Unknown

0.103

1.578

0.911–2.734

0.998

0.999

0.537–1.86