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Table 5 Overall mortality predictors in COVID-19 HM patients

From: COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

  Univariable Multivariable
  p value HR 95% CI p value HR 95% CI
Sex
Female
Male 0.059 1.119 0.095–1.258 0.376 1.065 0.927–1.223
Age  < 0.0001 1.036 1.031–1.041  < 0.0001 1.032 1.026–1.039
Malignancy status
Controlled disease
Active disease  < 0.0001 2.107 1.863–2.383  < 0.0001 1.860 1.615–2.141
Unknown  < 0.0001 2.293 1.607–3.274  < 0.0001 2.353 1.538–3.601
Hematological malignancy
Hodgkin lymphoma
Chronic lymphoid leukemia  < 0.0001 2.789 1.635–4.757 0.763 1.093 0.614–1.947
Acute myeloid leukemia  < 0.0001 4.364 2.581–7.376 0.011 2.046 1.176–3.557
Chronic myeloid leukemia 0.915 0.963 0.481–1.928 0.086 0.513 0.239–1.099
Acute lymphoblastic leukemia 0.002 2.530 1.405–4.553 0.250 1.457 0.767–2.768
Non-Hodgkin lymphoma  < 0.0001 3.041 1.814–5.100 0.569 1.171 0.68–2.015
Aplastic anemia 0.040 2.695 1.045–6.948 0.179 2.022 0.724–5.645
Essential thrombocythemia 0.234 1.585 0.742–3.387 0.332 0.667 0.295–1.511
Multiple myeloma  < 0.0001 3.355 1.989–5.658 0.630 1.145 0.661–1.984
Myelodysplastic syndrome  < 0.0001 4.627 2.704–7.919 0.072 1.706 0.953–3.056
Myelofibrosis  < 0.0001 3.786 2.110–6.791 0.185 1.540 0.813–2.915
Polycythemia vera 0.059 2.016 0.973–4.176 0.985 0.992 0.456–2.158
Amyloidosis 0.893 1.150 0.152–8.705 0.932 - -
Hairy cell leukemia 0.019 2.936 1.197–7.202 0.301 1.806 0.589–5.533
Systemic mastocytosis 0.715 1.457 0.192–11.031 0.968 0.959 0.126–7.323
COVID-19 infection
Asymptomatic
Mild infection 0.545 1.087 0.830–1.422 0.653 1.074 0.786–1.467
Severe infection  < 0.0001 2.127 1.722–2.628  < 0.0001 1.682 1.312–2.157
Critical infection  < 0.0001 5.333 4.300–6.613  < 0.0001 4.230 3.294–5.432
Unknown 0.623 1.229 0.540–2.800 0.928
Chronic cardiopathy  < 0.0001 2.011 1.792–2.257  < 0.0001 1.406 1.218–1.624
Liver disease 0.008 1.394 1.091–1.781 0.020 1.388 1.052–1.831
Chronic pulmonary disease  < 0.0001 1.516 1.320–1.740 0.926 1.008 0.85–1.195
Diabetes mellitus  < 0.0001 1.352 1.172–1.560 0.439 1.070 0.901–1.272
Obesity 0.796 0.974 0.796–1.191
Renal impairment  < 0.0001 1.883 1.589–2.232  < 0.0001 1.404 1.143–1.724
Smoking history 0.013 1.224 1.043–1.436 0.031 1.223 1.019–1.469
Neutrophils, cells/mm3
≤ 0.5 × 109/mm3
0.501-0.999 × 109/mm3  < 0.0001 0.594 0.450–0.785 0.272 0.845 0.626–1.141
 ≥ 1 × 109/mm3  < 0.0001 0.514 0.431–0.614 0.184 0.862 0.693–1.073
Lymphocytes, cells/mm3
≤ 0.2 × 109/mm3
0.201-0.499 × 109/mm3 0.004 0.746 0.611–0.912 0.021 0.779 0.629–0.963
 ≥ 0.5 × 109/mm3  < 0.0001 0.499 0.422–0.590  < 0.0001 0.601 0.499–0.722
Last chemotherapy
 > 3 months before COVID-19
In the last 3 months  < 0.0001 1.531 1.226–1.912 0.081 1.236 0.974–1.568
In the last month  < 0.0001 1.688 1.408–2.024 0.657 1.047 0.854–1.284
Unknown 0.103 1.578 0.911–2.734 0.998 0.999 0.537–1.86
  1. HR Hazard ratio, CI confidence intervals