Table 1 The roles of GAPs in RCD

p120RasGAP (RASA1)

Apoptosis

up/down

RAS, N-terminal fragment

Hepatocellular carcinoma, capillary malformation-arteriovenous malformation

[16, 28]

RGS3

Apoptosis

up

MEK/ERK

Hepatocellular carcinoma

[19]

STARD13

Apoptosis

up

Bax

Breast cancer

[20]

DLC1

Apoptosis

up

NF-кB

Angiosarcoma

[21]

DAB2IP

Apoptosis

up

STAT3, β-amyloid

Prostate cancer, Alzheimer's disease

[23, 30]

RACGAP1

Apoptosis

down

Hippo signaling pathway

Hepatocellular carcinoma

[24]

RGS5

Apoptosis

down

JNK1/2 and p38 signaling pathways

Cardiomyocytes

[29]

TBC1D17

Apoptosis

down

Rab12

Optic neuropathy

[31]

OATL1

Autophagy

down

RAB33B

Autophagosome maturation

[45]

TSC1/2

Autophagy

up

Rheb-mTORC1-ULK1 signaling pathway

Tuberous sclerosis complex

[51]

RalGAP

Autophagy

down/up

RalB, mTORC1

Autophagosome formation

[47, 53]

DAB2IP

Autophagy

down

Wnt/β-catenin signaling pathway, mTOR-S6K pathway

Glioblastoma, prostate cancer

[54, 55, 57]

SIPA1L2

Autophagy

down

TrkB/LC3b

Neurotransmitter liberation

[58]

TBC1D5

Autophagy

down

Rab7a

Neurodegenerative diseases, glucose uptake

[61, 67]

TBC1D15

Autophagy

down

RAB7

Neurodegenerative diseases

[62, 63]

SGSM3/RABGAP5

Autophagy

down

RAB5

Ehrlichia infection

[64]

TBC1D10A

Autophagy

down

Rab35-NDP52

Autophagosome formation

[65]

TBC1D20

Autophagy

down

RAB1B

Warburg Micro syndrome 4

[66]

TBC1D2

Ferroptosis

down

RAB7A

Lipid degradation

[75]

YopE

Pyroptosis

up

Rho GTPase

Yersinia infection

[79]

p190A RhoGAP

Entosis

up/down

Rho-ROCK signaling

Cell adhesion and cytoskeletal rearrangement

[84]

NF1

Mitotic catastrophe

up

RAS

Mitotic arrest

[89]

p190RhoGAP

Mitotic catastrophe

up

RhoA

Neoplastic multinucleation

[90]

RanGAP1

Mitotic catastrophe

up

Mitotic localization

Abnormal spindle formation

[91]

GIT1

Methuosis

up/down

Arf6

Vacuoles formation

[94,95,96]