Skip to main content
Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation

Fig. 2

Genomic characterization of LUSC transformation. a Bar blot showing number of mutations occurring specifically in the T-LUAD (blue) and T-LUSC (red) components, and of mutations shared between these (green). b Oncoprint showing the most prevalent mutations and CNAs in the transformation samples. c Volcano plot showing enrichment (as shown by odds ratio, OR) of genomic alterations in our T-LUAD samples, compared to the TCGA LUAD samples, used as control cohort. d Barplot showing the percentage of cases harboring mutations in genes of interest in the T-LUAD (red) and TCGA LUAD (blue) cohorts. Samples IDs in black indicate that they come from a combined histology specimen where LUAD and LUSC components are genetically related. Samples IDs in blue indicate that they come from a combined histology specimen where LUAD and LUSC components are genetically unrelated. Samples IDs in red indicate that they come from a pre-/post-transformation specimen

Back to article page