Fig. 2

The clinical relevance of integrin genes. a, b Mutational landscape of genes encoding integrins in 32 human cancers. Shown are bar plots illustrating the cumulative aberration frequencies of all 26 integrin genes combined (a) and heatmaps displaying the genetic alterations of individual integrin gene (b) cross human cancer types. c–e The clinical relevance of the most amplified integrin subunit ITGA10, encoding α10 integrin, in 32 human cancers. Shown are pan-cancer mutational landscape of ITGA10 (c), pairwise comparison of ITGA10 mRNA expression between normal and tumor tissues in indicated TCGA cancer types (d), and Kaplan–Meier plots illustrating ITGA10 as an unfavorable and a favorable gene associated with patient overall survival in indicated cancer types, respectively (e). (f–h) The clinical relevance of the most deleted integrin subunit ITGA1, encoding α1 integrin, in 32 human cancers. Shown are pan-cancer mutational landscape of ITGA1 (f), pairwise comparison of ITGA1 mRNA expression between normal and tumor tissues in indicated TCGA cancer types (g), and Kaplan–Meier plots illustrating ITGA1 as an unfavorable gene associated with patient overall survival in indicated cancer types (h). Data derived from TCGA pan-cancer analysis encompassing 10,953 patients representing 32 cancer types was viewed through cBioPortal. Gene expression and survival analysis were visualized via online database UALCAN (http://ualcan.path.uab.edu/index.html)