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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma

Fig. 2

Proteomic stratification of samples included and their clinicopathologic relevance. a Heatmap for the differentially expressed proteins among the tree subgroups (n = 1,009, Kruskal–Wallis test, Benjamini–Hochberg adjusted P < 0.05). b Metabolic pathway activities in each proteomic subgroups, with statistically non-significant values (random permutation test P > 0.05) shown as blank. c Proportion of patients with early relapse in each subgroups (left panel, Fisher’s exact test); Kaplan–Meier curves for recurrence-free survival based on proteomic subgroups (right panel, Log-rank test). d Proportion of S1 and S3 subgroups with early relapse at different TNM stages (left panel, Fisher’s exact test); Kaplan–Meier curves for recurrence-free survival of S1 and S3 subgroups at different TNM stages (right panel, Log-rank test). e Quantifications of p62 protein in each subgroup (Kruskal–Wallis test). fg The heatmap (f) and GSEA results (g) of significantly differentially expressed proteins (Kruskal–Wallis test, Benjamini–Hochberg adjusted P < 0.05) in patients diagnosed with or without tumor thrombus, among which the 31 differentially expressed metabolism-related proteins were labeled on the right side of the heatmap

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