Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers

Table 1 TAMs differentiation under the influence of tumor microenvironment

Tumor type	Pathway	Differentiation	References
Breast cancer	Lactate/Gpr132	Pro-M2 polarization	[16]
	Lactate/ERK/STAT3	Pro-M2 polarization	[17]
	Emodin/STAT6/C/EBPβ	Anti-M2 polarization	[18]
	MCT-1/miR-34a/IL-6/IL-6R	Pro-M2 polarization	[19]
	miR-200c/PAI-2	Pro-M2 polarization	[20]
Ovarian cancer	CTHRC1/STAT6	Pro-M2 polarization	[21]
	PPARγ/NF-κB	Pro-M2 polarization	[22]
Endometrial cancer	miRNA-21	Pro-M2 polarization	[48]
	lncRNA NIFK-AS1	Anti-M2 polarization	[23]
	rCTHRC1/CX3CR1	Pro-M2 polarization	[24]
Cervical cancer	Interleukin-17/COX-2/PGE2	Pro-M2 polarization	[25]
Lung cancer	Succinate/SUCNR1/PI3K-HIF-1α	Pro-M2 polarization	[26]
Colorectal cancer	PKN2/DUSP6-Erk1/2	Anti-M2 polarization	[27]
	PKCα/MKK3/6-P38 MAPK	Pro-M1 polarization	[28]
	EGFR/PI3K/AKT/mTOR	Pro-M2 polarization	[29]
	SPON2/integrin β1/PYK2	Pro-M2 polarization	[30]
Gastric cancer	TLR4/PI3K/Akt	Pro-M2 polarization	[31]

ISSN: 1756-8722