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Table 1 Basic concepts of primary lipids

From: Contradictory roles of lipid metabolism in immune response within the tumor microenvironment

Source

Key enzymes

Category

Functions

Regulators

References

Exogenous

CD36

FATP

MAGT

DAGT

LDLR

Fatty acid

FAO

ACS

CPT1

[22, 23, 26,27,28,29,30]

Endogenous

ACLY

ACC

FASN

Regulate signaling pathways and gene transcription

PPARs

SREBP-1

Physical processes and component formation

 

Exogenous

LDLR

VLDLR

CE synthesis

ACAT

[31,32,33,34, 37,38,39]

Endogenous

HMGCR

Cholesterol

Cholesterol efflux

ABCA1

ABCG1

 

Regulate signaling pathways and gene transcription

LXRs

Physical process and component formation

 

Endogenous

 

Lipid droplet

Store energy

ATGL

HSL

MAGL

LAL

[41,42,43,44]

Keep lipid metabolism balance