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Table 2 HLA alleles associated with asparaginase hypersensitivity

From: HLA alleles associated with asparaginase hypersensitivity in Chinese children

HLA alleles

OR (95% CI)

p value

Adjusted OR# (95% CI)

Adjusted p value#

HLA allele associated with at least one asparaginase hypersensitivity

    

B*51:01

1.2 (0.5–3.1)

0.81

NA

NA

HLA alleles associated with l-asparaginase hypersensitivity

    

B*46:01

3.8 (1.4–10.1)

 < 0.01*

3.5 (1.3–10.5)

0.02*

B*51:01

1.3 (0.5–3.4)

0.81

NA

NA

DRB1*09:01

4.3 (1.6–11.4)

 < 0.01*

4.4 (1.6–13.3)

 < 0.01*

  1. CI, confidence interval; HLA, human leukocyte antigen; NA, not applicable; and OR, odds ratio
  2. *p < 0.05
  3. #Adjusted for, age, gender and the diagnosis of B cell acute lymphoblastic leukaemia