Fig. 2

A Hierarchical clustering of genes expression of the AML cells in the BM for the group of empty micelle and ^mPO-6 at 24 h post injection. Blue and red colors represented down-regulated or up-regulated genes respectively (n = 4). B Cluster of genes that were analyzed by Kyoto Encyclopedia of Genes and Genomes (KEGG) for identification of the affected biological processes with the treatment of ^mPO-6. C Genes were alternated significantly in the BM related to the CD123/IL-3 axis (n = 4). D The phosphorylation of STAT5, PI3K/AKT and the expression of NF-κB in the nucleus, cytoplasm and total protein in the group of empty micelle and ^mPO-6. Leukemia cells were separated from the BM of the AML mice scarified 24 h after the third i.v. injection of empty micelles or ^mPO-6. E Histologic sections of BM in the mice stained with H&E, the yellow arrows pointed normal cells. The expression of CD123 on AML cells in the BM F and PB G was reduced by ^mPO-6 (n = 4). *P < 0.05, **P < 0.01