Table 2 Clinical studies using MSC-based therapies for cancer treatment

Tissue-derived MSC

Hematopoietic and lymphoid cell neoplasm

Cord blood MSCs

I/II

NCT04565665

Acute leukemia

IFNγ-primed bone marrow MSCs

I

NCT04328714

Pancreatic cancer

Adipose MSCs

I

NCT04087889

Mandible tumor

Adipose MSCs

I/II

NCT03678467

Acute respiratory distress syndrome (ARD) in patients with malignancies

Bone marrow MSCs

I

NCT02804945

Myelodysplastic syndromes

Cord blood MSCs

I/II

NCT03184935

Rectal cancer

NeuroRegen Scaffold™ + Cord blood MSCs

I/II

NCT02648386

Hematologic malignancies

MSCs

I

NCT02181478

Prostate cancer

Bone marrow MSCs

I

NCT01983709

Expanding umbilical cord blood derived blood stem cells for treating leukemia, lymphoma, and myeloma

Bone marrow MSCs

I/II

NCT01624701

Solid organ cancers

MSCs

I

NCT01275612

Hematological malignancies

Cord blood transplantation + MSCs

I/II

NCT01092026

Leukemia, lymphoma, and myeloma

Hematopoietic stem cells + MSCs

II

NCT01045382

Bone neoplasms

Pre-immunodepleted MSCs

II/III

NCT00851162

Myelodysplastic syndromes

Cord blood MSCs

II

NCT01129739

Engineered MSC

Ovarian cancer

MSCs secreting INF-β

I

NCT02530047

Adenocarcinoma of lung

MSCs secreting TRAIL + standard therapy

I

NCT03298763

Diffuse intrinsic pontine glioma

Radio therapy + Bone marrow MSCs infected with oncolytic virus

I

NCT04758533

Glioma

Bone marrow MSCs infected with oncolytic virus

I

NCT03896568

Head and neck cancer

MSCs secreting IL-12

I

NCT02079324

Ovarian, primary peritoneal or fallopian tube cancer

Adipose MSCs infected with oncolytic virus

I/II

NCT02068794

Metastatic and refractory tumors

Bone marrow MSCs infected with oncolytic virus

I/II

NCT01844661

MSC-derived exosome

Metastatic pancreas cancer

MSCs-derived exosomes with KRAS G12D siRNA

I

NCT03608631