Fig. 1

Structure of STAT proteins. Schematic illustration of a representative STAT protein showing its six conserved functional domains: N-terminal, coiled-coil, DNA-binding, linker, Src-homology 2 (SH2) and C-terminal. The positions of a nuclear localization signal (NLS) and tyrosine (Y) and serine (S) residues phosphorylated in response to extracellular stimuli are shown, along with the sites of interaction of various transcriptional co-activators (green) and co-repressors (red)