Fig. 3

Alternative STAT functional modalities. Schematic depiction of alternate modes by which STATs can impact on cellular functions: A inducible transcriptional activation (‘canonical’ signaling), B inducible transcriptional repression, C basal transcriptional activation, D basal transcriptional repression, E inducible non-nuclear function, F basal non-nuclear function. Shown are unphosphorylated STAT (uSTAT) molecules and their conversion into phosphorylated STAT (pSTAT) molecules and their dimerization where appropriate, as well as their movement between the cytoplasm, nucleus and other cellular compartments, along with the molecular function(s) that they exert in each case