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Table 1 Functions of mammalian STAT proteins in immunity

From: STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer

STAT protein

Major functions

References

STAT1

Immunity against viral and bacterial infection

[7, 8]

STAT2

Immunity against viral and bacterial infection

[7, 8]

STAT3

Regulation of innate immunity and inflammation, stem cell maintenance, cell metabolism

[9, 10]

STAT4

Development and function of adaptive and innate immune cells

[11, 12]

STAT5A/B

Development of multiple blood and immune cell lineages

[13]

STAT6

Regulation of innate and humoral immunity

[14, 15]